Zeolitic imidazolate framework-8(ZIF-8)is a metal-organic framework material with unique physical and chemical properties.The signal amplification strategy based on ZIF-8 as the host combined with a large number of guest signal molecules is one of the promising research directions for the development of novel detection methods.In recent years,the development of accurate and sensitive detection methods for biomarkers and the revelation of their association with various diseases have become a research hotspot.The biosensor based on ZIF-8 can detect biomarkers with high sensitivity,rapid response,low cost and high selectivity,which can provide a new way of thinking for disease screening,diagnosis and prognosis in medical and health care work.
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