ZIF-8构建生物标志物传感器研究进展
Recent Developments in ZIF-8 for Biomarker Biosensor
范炳华 1张建军 2刘越 3吴拥军 1王艺琳1
作者信息
- 1. 郑州大学 公共卫生学院,河南郑州 450001
- 2. 河南省市场监督管理局食品安全和应急保障中心,河南郑州 450000
- 3. 河南省食品和盐业检验技术研究院,河南郑州 450000
- 折叠
摘要
沸石咪唑骨架-8(ZIF-8)是一种金属-有机框架材料,具有独特的理化性质,基于ZIF-8 作为主体结合大量客体信号分子的信号放大策略是开发新型检测方法的有前景的研究方向之一.生物标志物的准确、灵敏的检测方法的开发以及揭示其与各种疾病之间的联系是近年来的研究热点.基于ZIF-8 构建的生物传感器能够高灵敏度、快速响应、低成本、高选择性地检测生物标志物,可以为医疗卫生工作中疾病的筛查、诊断、预后工作提供一种新的思路.
Abstract
Zeolitic imidazolate framework-8(ZIF-8)is a metal-organic framework material with unique physical and chemical properties.The signal amplification strategy based on ZIF-8 as the host combined with a large number of guest signal molecules is one of the promising research directions for the development of novel detection methods.In recent years,the development of accurate and sensitive detection methods for biomarkers and the revelation of their association with various diseases have become a research hotspot.The biosensor based on ZIF-8 can detect biomarkers with high sensitivity,rapid response,low cost and high selectivity,which can provide a new way of thinking for disease screening,diagnosis and prognosis in medical and health care work.
关键词
沸石咪唑骨架-8(ZIF-8)/生物传感器/生物标志物Key words
zeolitic imidazolate framework-8(ZIF-8)/biosensor/biomarker引用本文复制引用
基金项目
国家市场监督管理总局技术保障专项项目(2023YJ20)
河南省自然科学基金项目(222300420302)
出版年
2024
NETL
NSTL
万方数据