布鲁氏菌与宿主相互作用的机制及其新型疫苗的研究进展
Research Progress of Brucella-Host Interaction Mechanism and Novel Vaccines
张静杰 1杨德志 2福泉1
作者信息
- 1. 内蒙古医科大学附属医院 检验科,内蒙古呼和浩特 010110
- 2. 内蒙古国际蒙医医院 药物实验室,内蒙古呼和浩特 010065
- 折叠
摘要
布鲁氏菌病是由布鲁氏菌感染引起的人畜共患性传染病,如果不及时治疗,可能导致严重的并发症.现有的兽用疫苗存在诱发感染的风险,不适合用于人类.随着分子生物技术的快速发展,重组蛋白疫苗、核酸疫苗等新型疫苗逐渐成为研究热点.本文探讨了在布鲁氏菌感染过程中,免疫逃逸和病原体与宿主相互作用的机制,并对近年来新型疫苗的研究进展情况进行综述,以期为布鲁氏菌病疫苗的研究与开发提供新的思路.
Abstract
Brucellosis is a zoonotic infection caused by Brucella infection that can lead to serious complications if left untreated.Existing veterinary vaccines carry the risk of inducing infection and are not suitable for use in humans.With the rapid development of molecular biotechnology,recombinant protein vaccine,nucleic acid vaccine and other new vaccines have gradually become the focus of research.In this paper,the mechanisms of immune escape and pathogen-host interaction during brucellosis infection are discussed,and the research progress of novel vaccines in recent years is reviewed in order to provide new ideas for the research and development of brucellosis vaccines.
关键词
布鲁氏菌病/免疫逃逸机制/疫苗Key words
brucellosis/immune escape mechanism/vaccines引用本文复制引用
基金项目
内蒙古自治区自然科学基金项目(2021ZD16)
出版年
2024
NETL
NSTL
万方数据