The Therapeutic Effect of Qingkailing on the Combination of Disease and Syndrome Model of Human Coronavirus Pneumonia with Cold Dampness Virus Attacking Lung
The Therapeutic Effect of Qingkailing on the Combination of Disease and Syndrome Model of Human Coronavirus Pneumonia with Cold Dampness Virus Attacking Lung
Objective:To construct an animal model of cold dampness virus attacking lung,and to investigate the mechanism of action of Qingkailing injection.Methods:The pharmacodynamics of mice are evaluated from the aspects of phenotypic appearance,serum motilin(MTL)and gastrin(GAS)content,lung index and inhibition rate,expression of viral nucleic acid and inflammatory factors in lung tissue.Results:Compared with the cold-damp infection group,the lung index of mice is significantly increased(p＜0.01),and the lung index of the low-dose and high-dose administration groups is significantly decreased(p＜0.01),and the inhibition rates of lung index are 82.20%and 69.12%,respectively.Qingkailing injection can significantly improve the general state of infected mice,significantly reduce lung inflammation in mice,reduce the expression of viral nucleic acids,the content of inflammatory factors such as interleukin-6(IL-6)in the lung tissues of mice,and the content of MTL and GAS in serum,and increase the percentage of lymphocytes.Conclusion:Qingkailing injection has obvious therapeutic effect on the pulmonary syndrome of cold dampness virus attack of human coronavirus pneumonia.
维普
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