In order to evaluate the toxicity of stephanine in collagen-induced arthritis mice body weight,liver and kidney,after modeling,the mice are administered 1.5 mg/kg adalimumab(positive group)or 2 mg/kg stephanine(drug group),monitor the body weight,liver weight and kidney weight,and histological morphology is observed by H&E staining.The experimental results show that 2 mg/kg stephanine has no significant effect on the body weight of CIA model mice,and has no toxicity to the liver and kidney.2 mg/kg stephanine has no effect on the body weight of CIA mice,and does not cause pathological changes in the liver and kidney of CIA mice,which is a safe dose.
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