The P2X7 purinergic receptor is a non-selective trimer cation channel that is open by extracellular ATP activation.It has characteristics such as low affinity for adenosine triphosphate(ATP),difficulty in desensitization,and macropore opening.P2X7R is widely expressed in immune and tumor cells,and it is thought to be strongly associated with cancers and a possible target for anti-tumor drugs.Most opinions believe that P2X7R is up-regulated in tumors,and its inhibitors can inhibit the development of tumors.However,due to the complex effects of P2X7R on tumor microenvironment(TME),especially immune cells in TME,clinical research on P2X7R inhibitors has progressed slowly.This work focuses on P2X7R's impacts on tumors and TME,summarizing recent research findings.
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