Exercise is an effective strategy for the prevention and treatment of metabolism-related diseases such as obesity and insulin resistance.Exerkines factors are soluble signaling factors induced by exercise,mainly including hepatokines,myokines and adipokines,which play an important role in the regulation of body metabolism by exercise.Exerkines can increase the oxidative decomposition of fat in the body,induce browning of white adipose tissue,optimize the body's energy redistribution,control appetite and energy expenditure,and reduce systemic inflammation and insulin resistance.At present,the main known hepatokines are fibroblast growth factor 21,angiopoietin-like protein 4 and follistatin,myokines mainly include interleukin 6,irisin,myostatin and β-aminoisobutyric acid,and adipokines are mainly leptin and adiponectin.This article mainly summarizes the functions of these exerkines,the metabolic pathways involved during exercise,and the mechanism of tandem regulation of various organs.
维普
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