As a substitute for H2O2,CaO2 nanoparticles are simple to prepare and widely used.It plays an important role in controlling environmental pollution through Fenton reaction and other mechanisms.However,because CaO2 reacts with water to produce H2O2 and O2 at a faster rate,it is usually necessary to wrap a layer of high molecular material on its surface as a sustained release agent.This paper mainly introduces different preparation methods of CaO2 nanoparticles,different sustained release agents used in the process,and the application progress of CaO2 nanoparticles combined with bacteria,Fe2+,O3,etc.,to treat different pollutants,including trichloroethylene,oxytetracycline,aromatic pollutants,heavy metals.