Analysis of the Mechanism of Astragaloside Ⅳ in the Treatment of Cardiovascular Diseases Based on Network Pharmacology and Molecular Docking
The mechanism of astragaloside Ⅳ(AS-Ⅳ)in the treatment of cardiovascular disease(CVD)is studied by network pharmacology and molecular docking technology.AS-Ⅳ and CVD targets are screened for protein-protein interaction(PPI)analysis,and a target-pathway network for AS-Ⅳ treatment of CVD is constructed.The KEGG PATHWAY database is used to analyze the PI3K(phosphoinositide 3-kinase)-AKT(serine-threonine kinase)signaling pathway.A total of 57 intersection targets are screened,and 471 GO entries are obtained,involving signal transduction,apoptosis,etc.A total of 105 KEGG pathways are screened out,including PI3K-AKT,endothelial growth factor receptor(EGFR),etc.The top 5 targets are AKT1,EGFR,sarcoma(SRC),vascular endothelial growth factor A(VEGFA)and signal transducer and activator of transcription 3(STAT3).The results of molecular docking showed that AS-Ⅳ has a good binding force with these key receptors,indicating that AS-Ⅳ has a potential role in multi-target and multi-pathway treatment of cardiovascular diseases.
astragaloside ⅣPI3K-AKT signal pathwaynetwork pharmacologymolecular docking
NETL
NSTL
万方数据
维普
