纳米技术在精子冷冻保存中的应用
Application of Nanotechnology in Cryopreservation of Sperm
胡焕焕 1孙志彬 1赵枭阳 2王晓仪 1李文秘 1王晴晴 1杜好语 1姬国杰1
作者信息
- 1. 新乡医学院三全学院 生育力保存重点实验室,河南 新乡 453000
- 2. 郑州伊美诺生物技术有限公司,河南 郑州 450000
- 折叠
摘要
精子低温保存是人工授精和动物种质资源保存的主要技术.在低温保存及复温过程中,精子的运动性、完整性、活力等会受到一定的损伤,从而影响精子的受精能力.纳米颗粒(Nanoparticles,NPs)可以防御低温保存过程中产生的自由基和氧化应激.随着纳米技术的发展以及不同性质的NPs材料的广泛选择和修饰选择,定制的纳米颗粒已经被开发用于精子冷冻保存领域,并显示出冻融过程中修复损伤精子的再生能力.为了认识这一潜力,本综述重点关注了金属/含金属纳米颗粒、非金属元素纳米颗粒、生物活性分子纳米颗粒、纳米囊泡等在精子冷冻保存领域的应用.
Abstract
The cryopreservation of sperm is a primary technique utilized for artificial insemination and the conservation of animal germplasm resources.During cryopreservation and rewarming,sperm motility,integrity,and vitality are compromised,thereby impacting sperm fertilization potential.Nanoparticles(NPs)have demonstrated the ability to protect against free radicals and oxidative stress that occur during cryopreservation.The advancement of nanotechnology has led to the creation of a diverse array of NPs materials with varying properties and customization options.These tailored nanoparticles have been specifically designed for use in sperm cryopreservation and have exhibited regenerative capabilities in repairing damaged sperm during the freeze-thaw process.This review examines the utilization of metal/metal-containing nanoparticles,non-metallic element nanoparticles,bioactive molecular nanoparticles,and nanovesicles in the cryopreservation of sperm in order to elucidate their potential applications in this field.
关键词
纳米技术/冷冻保存/精子/DNA损伤/氧化应激Key words
nanotechnology/cryopreservation/sperm/DNA damage/oxidative stress引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据