Role and Mechanism of Lipids in the Regulation of TRPV1 Activity
Transient receptor potential vanilloid subtype 1(TRPV1)channel is a non-selective cation channel that is mainly permeable to Ca2+on the cell membrane,which can be activated by endogenous and exogenous factors,and is involved in physiological and pathological processes such as inflammation,pain,and itching.In this review,we summarize the regulatory effects of several lipids on TRPV1 channels,and discuss the mechanisms revealed by structural biology research for reference.