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脂质在TRPV1活性调节中的作用及机制

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瞬时受体电位香草酸亚型 1(TRPV1)通道是表达在细胞膜上主要通透Ca2+的非选择性阳离子通道,可被内源性和外源性因子激活,参与炎症、疼痛和瘙痒等生理病理过程.本文总结了几种脂质对TRPV1 通道的调节作用,并从结构生物学研究所揭示的机制上展开讨论,以供参考.
Role and Mechanism of Lipids in the Regulation of TRPV1 Activity
Transient receptor potential vanilloid subtype 1(TRPV1)channel is a non-selective cation channel that is mainly permeable to Ca2+on the cell membrane,which can be activated by endogenous and exogenous factors,and is involved in physiological and pathological processes such as inflammation,pain,and itching.In this review,we summarize the regulatory effects of several lipids on TRPV1 channels,and discuss the mechanisms revealed by structural biology research for reference.

lipidstransient receptor potential vanilloid subtype 1(TRPV1)mechanism

周怡、汪津

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中国药科大学 基础医学与临床药学学院,江苏 南京 210009

脂质 瞬时受体电位香草酸亚型1(TRPV1) 机制

2024

生物化工

生物化工

ISSN:
年,卷(期):2024.10(5)