首页|Various mechanisms in cyclopeptide production from precursors synthesized independently of non-ribosomal peptide synthetases

Various mechanisms in cyclopeptide production from precursors synthesized independently of non-ribosomal peptide synthetases

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An increasing number of cyclopeptides have been discovered as products of ribosomal synthetic pathway.The biosynthetic study of these cyclopeptides has revealed interesting new mechanisms for cyclization.This review highlighted the recent discoveries in cyclization mechanisms for cyclopeptides synthesized independently of non-ribosomal peptide synthetases,including endopeptidase-catalyzed cyclization,intein-mediated cyclization,and peptide synthetase-catalyzed cyclization.This information may help to design hybrid ribosomal and non-ribosomal biosynthetic systems to produce novel cyclopeptides with various bioactivities.

ribosomal peptidecyclopeptidesnon-ribosomal peptide synthetasecyclization mechanism

Wenyan Xu、Liling Li、Liangcheng Du、Ninghua Tan

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State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China

Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA

Graduate University of Chinese Academy of Sciences, Beijing 100049, China

grants from the National Natural Science Foundation of Chinagrants from the National Natural Science Foundation of Chinagrants from the National Natural Science Foundation of Chinagrants from the National Natural Science Foundation of ChinaChinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of ScieNational Institute of Health of USAChina Scholarship Council

30725048U103260291013002KSCX2-YW-R-177RR015468-01

2011

10.1093/abbs/gmr062

生物化学与生物物理学报(英文版)
中国科学院上海生物化学研究所

生物化学与生物物理学报(英文版)

CSTPCDCSCDSCI
影响因子：0.772
ISSN：1672-9145
年,卷(期)：2011.43(10)
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