首页|lncRNA-Gm5532 regulates osteoclast differentiation through the miR-125a-3p/TRAF6 axis

lncRNA-Gm5532 regulates osteoclast differentiation through the miR-125a-3p/TRAF6 axis

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Long noncoding RNAs(lncRNAs)are important regulators of bone metabolism.In this study,lncRNA microarray analysis was used to identify differentially expressed lncRNAs in differentiated osteoclasts.lncRNA-Gm5532 is highly expressed during osteoclast differentiation.lncRNA-Gm5532 knockdown impairs osteoclast formation and bone resorption.Mechanistic experiments show that lncRNA-Gm5532 functions as a competing endogenous RNA(ceRNA)and acts as a sponge for miR-125a-3p,which promotes TNF receptor-associated factor 6(TRAF6)ex-pression.miR-125a-3p mimics suppress osteoclast differentiation and TAK1/NF-κB/MAPK signaling.The miR-125a-3p inhibitor reverses the negative effects of siGm5532 on osteoclast differentiation.In summary,our study reveals that lncRNA-Gm5532 functions as an activator in osteoclast differentiation by targeting the miR-125a-3p/TRAF6 axis,making it a novel biomarker and potential therapeutic target for osteoporosis.

lncRNA-Gm5532osteoclast differentiationmiR-125a-3pTNF receptor-associated factor 6(TRAF6)

Jian Zhang、Lingyan Zhang、Gang Yao、Hai Zhao、Penghai Qiao、Shuguang Wu

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Institute of Laboratory Animal Science,Guizhou University of Traditional Chinese Medicine,Guiyang 550021,China

国家自然科学基金Guizhou Education Department Youth Science and Technology Talents Growth Project贵州省科技计划

82060168Qian Jiao He KY Zi[2021]199Qian Ke He Ji Chu-ZK[2021]-Yi Ban 398

2024

10.3724/abbs.2023245

生物化学与生物物理学报(英文版)
中国科学院上海生物化学研究所

生物化学与生物物理学报(英文版)

CSTPCD
影响因子：0.772
ISSN：1672-9145
年,卷(期)：2024.56(1)
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