首页|κ-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-κB pathway

κ-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-κB pathway

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
Osteoarthritis(OA)is a prevalent and chronic joint disease that affects the aging population,causing pain and disability.Macrophages in synovium are important mediators of synovial inflammatory activity and pathological joint pain.Previous studies have demonstrated the significant involvement of κ-opioid receptor(KOR)in the reg-ulation of pain and inflammation.Our study reveals a significant reduction in synovial KOR expression among patients and mice with OA.Here,we find that KOR activation effectively inhibits the expressions of the LPS-induced-inflammatory cytokines TNF-a and IL-6 by inhibiting macrophage M1 phenotype.Mechanistically,KOR activation effectively suppresses the proinflammatory factor secretion of macrophages by inhibiting the translocation of NF-κB into the nucleus.Our animal experiments reveal that activation of KOR effectively alleviates knee pain and prevents synovitis progression in OA mice.Consistently,KOR administration suppresses the expressions of M1 macrophage markers and the NF-κB pathway in the synovium of the knee.Collectively,our study suggests that targeting KOR may be a viable strategy for treating OA by inhibiting synovitis and improving joint pain in affected patients.

synovial inflammationmacrophage polarizationκ-opioid receptorosteoarthritisNF-κB

Yi Shi、Huaqiang Tao、Xueyan Li、Liyuan Zhang、Chunhui Li、Wen Sun、Miao Chu、Kai Chen、Pengfei Zhu、Qiang Wang、Chengyong Gu、Liangliang Wang、Xing Yang、Yuefeng Hao

展开 >

Anesthesiology Department,Suzhou Municipal Hospital(North District),Nanjing Medical University Affiliated Suzhou Hospital,Suzhou 215000,China

Department of Orthopedics,the First Affiliated Hospital of Soochow University,Suzhou 215000,China

Department of Orthopedics,Changshu Hospital Affiliated to Soochow University,First People's Hospital of Changshu City,Changshu 215500,China

Department of Orthopedics,the Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University,Changzhou 213000,China

Orthopedics and Sports Medicine Center,Suzhou Municipal Hospital,Nanjing Medical University Affiliated Suzhou Hospital,Suzhou 215000,China

展开 >

Top Talent of ChangzhouProgram of Jiangsu Science and Technology DepartmentProgram of Jiangsu Science and Technology DepartmentSuzhou Municipal Health CommissionJiangsu Medical Research ProjectSpecial Project of Diagnosis and Treatment Technology for Key Clinical Diseases in SuzhouProgram of Suzhou Health CommissionProgram of Suzhou Health CommissionProgram of Suzhou Health CommissionSuzhou Health Commission Science Education and Health Youth Project

BK20211083BE2022737SKJY2021115ZD2022021LCZX202003GSWS2020078GSWS2022002SZXK202111KJXW2021040

2024

10.3724/abbs.2023223

生物化学与生物物理学报(英文版)
中国科学院上海生物化学研究所

生物化学与生物物理学报(英文版)

CSTPCD
影响因子：0.772
ISSN：1672-9145
年,卷(期)：2024.56(1)
  • 61