首页|ELF4 contributes to esophageal squamous cell carcinoma growth and metastasis by augmenting cancer stemness via FUT9

ELF4 contributes to esophageal squamous cell carcinoma growth and metastasis by augmenting cancer stemness via FUT9

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
Esophageal squamous cell carcinoma(ESCC)commonly has aggressive properties and a poor prognosis.In-vestigating the molecular mechanisms underlying the progression of ESCC is crucial for developing effective therapeutic strategies.Here,by performing transcriptome sequencing in ESCC and adjacent normal tissues,we find that E74-like transcription factor 4(ELF4)is the main upregulated transcription factor in ESCC.The results of the immunohistochemistry show that ELF4 is overexpressed in ESCC tissues and is significantly correlated with cancer staging and prognosis.Furthermore,we demonstrate that ELF4 could promote cancer cell proliferation,migration,invasion,and stemness by in vivo assays.Through RNA-seq and ChIP assays,we find that the stemness-related gene fucosyltransferase 9(FUT9)is transcriptionally activated by ELF4.Meanwhile,ELF4 is verified to affect ESCC cancer stemness by regulating FUT9 expression.Overall,we first discover that the transcription factor ELF4 is overexpressed in ESCC and can promote ESCC progression by transcriptionally upregulating the stemness-related gene FUT9.

esophageal squamous cell carcinomatranscription factorELF4FUT9stemness

Aiping Xu、Mingchuang Sun、Zhaoxing Li、Yuan Chu、Kang Fang、Yunwei Zhang、Jingjing Lian、Li Zhang、Tao Chen、Meidong Xu

展开 >

Endoscopy Center,Zhongshan Hospital,School of Medicine,Fudan University,Shanghai 200032,China

Endoscopy Center,Department of Gastroenterology,Shanghai East Hospital,School of Medicine,Tongji University,Shanghai 200120,China

Department of Gastroenterology and Hepatology,Jing'an District Centre Hospital,Fudan University,Shanghai 20032,China

Department of Pathology,Shanghai East Hospital,School of Medicine,Tongji University,Shanghai 200120,China

展开 >

国家自然科学基金国家自然科学基金上海市科委项目上海市科委项目上海市科委项目上海市科委项目Medical Discipline Construction Project of Pudong Health Committee of ShanghaiMedical Discipline Construction Project of Pudong Health Committee of Shanghai

820726848207322420XD140290021XD142310021JC140520018140900100PWZxq2022-6PWYgf2021-2

2024

10.3724/abbs.2023225

生物化学与生物物理学报(英文版)
中国科学院上海生物化学研究所

生物化学与生物物理学报(英文版)

CSTPCD
影响因子：0.772
ISSN：1672-9145
年,卷(期)：2024.56(1)
  • 25