首页|DPP3 promotes breast cancer tumorigenesis by stabilizing FASN and promoting lipid synthesis

DPP3 promotes breast cancer tumorigenesis by stabilizing FASN and promoting lipid synthesis

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DPP3,a dipeptidyl peptidase,participates in a variety of pathophysiological processes.DPP3 is upregulated in cancer and might serve as a key factor in the tumorigenesis and progression of various malignancies.However,its specific role and molecular mechanism are still unknown.In this study,the expression of DPP3 in breast cancer tissues is analyzed using TCG A database.Kaplan-Meier survival analysis is performed to estimate the effect of DPP3 on the survival outcomes.To explore the biological function and mechanisms of DPP3 in breast cancer,biochemical and cell biology assays are conducted in vitro.DPP3 expresses at a higher level in breast cancer tissues than that in adjacent tissues in both TCGA database and clinical samples.Patients with high expression of DPP3 have poor survival outcomes.The proliferation and migration abilities of tumor cells with stable DPP3 knockout in breast cancer cell lines are significantly inhibited,and apoptosis is increased in vitro.GSEA analysis shows that DPP3 can affect lipid metabolism and fatty acid synthesis in tumors.Subsequent experiments show that DPP3 could stabilize FASN expression and thus promote fatty acid synthesis in tumor cells.The results of the metabolomic analysis also confirm that DPP3 can affect the content of free fatty acids.This study demonstrates that DPP3 plays a role in the reprogramming of fatty acid metabolism in tumors and is associated with poor prognosis in breast cancer patients.These findings will provide a new therapeutic target for the treatment of breast cancer.

dipeptidyl peptidase 3fatty acid synthetasebreast cancer

Xiaoyu Fu、Xu Li、Weixing Wang、Juanjuan Li

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Department of Breast and Thyroid Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,China

Department of General Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,China

Hubei Key Laboratory of Cell Homeostasis,College of Life Sciences,TaiKang Center for Life and Medical Sciences,Wuhan University,Wuhan 430072,China

湖北省自然科学基金

2023BCB022

2024

10.3724/abbs.2024054

生物化学与生物物理学报(英文版)
中国科学院上海生物化学研究所

生物化学与生物物理学报(英文版)

CSTPCD
影响因子：0.772
ISSN：1672-9145
年,卷(期)：2024.56(5)
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