首页|Unraveling the metabolic potential of biocontrol fungi through omics data:a key to enhancing large-scale application strategies

Unraveling the metabolic potential of biocontrol fungi through omics data:a key to enhancing large-scale application strategies

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Biological control of pests and pathogens has attracted much attention due to its green,safe and effective char-acteristics.However,it faces the dilemma of insignificant effects in large-scale applications.Therefore,an in-depth exploration of the metabolic potential of biocontrol fungi based on big omics data is crucial for a comprehensive and systematic understanding of the specific modes of action operated by various biocontrol fungi.This article analyzes the preferences for extracellular carbon and nitrogen source degradation,secondary metabolites(nonribosomal peptides,polyketide synthases)and their product characteristics and the conversion relationship between extra-cellular primary metabolism and intracellular secondary metabolism for eight different filamentous fungi with characteristics appropriate for the biological control of bacterial pathogens and phytopathogenic nematodes.Further clarification is provided that Paecilomyces lilacinus,encoding a large number of hydrolase enzymes capable of degrading pathogen protection barrier,can be directly applied in the field as a predatory biocontrol fungus,whereas Trichoderma,as an antibiosis-active biocontrol control fungus,can form dominant strains on preferred substrates and produce a large number of secondary metabolites to achieve antibacterial effects.By clarifying the levels of biological control achievable by different biocontrol fungi,we provide a theoretical foundation for their application to cropping habitats.

omicsbiocontrol funginonribosomal peptides(NRPs)polyketide synthase(PKS)metabolic transformation

Haolin Yang、Xiuyun Wu、Caiyun Sun、Lushan Wang

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State Key Laboratory of Microbial Technology,Institute of Microbial Technology,Shandong University,Qingdao 266237,China

the grants from Key Research and Development Program of Shandong Province国家重点研发计划

2021CXGC0108032023YFC3403601

2024

生物化学与生物物理学报(英文版)
中国科学院上海生物化学研究所

生物化学与生物物理学报(英文版)

CSTPCD
影响因子:0.772
ISSN:1672-9145
年,卷(期):2024.56(6)
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