Prostate cancer-associated transcript 6(PCAT6)promotes epithelial-mesenchymal transition and stemness and worsens prognosis in patients with colorectal cancer

Xun Sun ¹Yitao Yuan ¹Suyao Li ¹Lu Gan ²Midie Xu ³Qingguo Li ⁴Mengling Liu ¹Keshu Hu ¹Ke Nan ⁵Jiayu Zhang ¹Yu Dong ¹Yufu Lin ⁶Xiuping Zhang ⁷Pengcong Hou ⁸Tianshu Liu⁹

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作者信息

1. Department of Medical Oncology,Zhongshan Hospital,Fudan University,Shanghai 200032,China
2. Department of Medical Oncology,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Cancer Center,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Fudan Zhangjiang Institute,Shanghai 201203,China
3. Department of Pathology and Tissue Bank,Fudan University Shanghai Cancer Center,Shanghai,200032,China
4. Department of Colorectal Surgery,Fudan University Shanghai Cancer Center,Shanghai,200032,China;Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China
5. Department of Anesthesiology,Zhongshan Hospital,Fudan University,Shanghai 200032,China
6. Department of Oncology,Zhongshan Hospital(Xiamen),Fudan University,Xiamen 361015,China
7. Xiamen Clinical Research Center for Cancer Therapy,Xiamen Branch,Zhongshan Hospital,Fudan University,Xiamen 361015,China
8. Department of Medical Oncology,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Shanghai Institute of Precision Medicine,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200032,China
9. Department of Medical Oncology,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Cancer Center,Zhongshan Hospital,Fudan University,Shanghai 200032,China
折叠

Abstract

Approximately 20％of colorectal cancer(CRC)patients are first diagnosed with metastatic colorectal cancer(mCRC)because they develop symptoms at an advanced stage.Despite advancements in treatment,patients with meta-static disease still experience inferior survival rates.Our objective is to investigate the association between long noncoding RNAs(IncRNAs)and prognosis and to explore their role in mCRC.In this study,we find that elevated expression of PCAT6 is independently linked to unfavourable survival outcomes in The Cancer Genome Atlas(TCGA)data,and this finding is further confirmed in CRC samples obtained from Fudan University Shanghai Cancer Center.Cell lines and xenograft mouse models are used to examine the impact of PCAT6 on tumor metastasis.Knockdown of PCAT6 is observed to impede the metastatic phenotype of CRC,as evidenced by functional assays,demonstrating the suppression of epithelial-mesenchymal transition(EMT)and stemness.Our findings show the significance of PCAT6 in mCRC and its potential use as a prognostic biomarker.

Key words

colorectal cancer/IncRNA/PCAT6/metastasis

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基金项目

国家自然科学基金(82172925)

国家自然科学基金(81802370)

国家自然科学基金(8217111492)

上海市自然科学基金(23ZR1421300)

Youth Foundation of Zhongshan Hospital Fudan University(2022ZSQN09)

Xiamen Natural Science Foundation Project(3502Z20227111)

Fujian provincial health technology project(2021QNB020)

出版年

2024

生物化学与生物物理学报(英文版)

中国科学院上海生物化学研究所

生物化学与生物物理学报(英文版)

CSTPCDCSCD

影响因子：0.772

ISSN：1672-9145

参考文献量36

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