首页|Prostate cancer-associated transcript 6(PCAT6)promotes epithelial-mesenchymal transition and stemness and worsens prognosis in patients with colorectal cancer

Prostate cancer-associated transcript 6(PCAT6)promotes epithelial-mesenchymal transition and stemness and worsens prognosis in patients with colorectal cancer

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Approximately 20%of colorectal cancer(CRC)patients are first diagnosed with metastatic colorectal cancer(mCRC)because they develop symptoms at an advanced stage.Despite advancements in treatment,patients with meta-static disease still experience inferior survival rates.Our objective is to investigate the association between long noncoding RNAs(IncRNAs)and prognosis and to explore their role in mCRC.In this study,we find that elevated expression of PCAT6 is independently linked to unfavourable survival outcomes in The Cancer Genome Atlas(TCGA)data,and this finding is further confirmed in CRC samples obtained from Fudan University Shanghai Cancer Center.Cell lines and xenograft mouse models are used to examine the impact of PCAT6 on tumor metastasis.Knockdown of PCAT6 is observed to impede the metastatic phenotype of CRC,as evidenced by functional assays,demonstrating the suppression of epithelial-mesenchymal transition(EMT)and stemness.Our findings show the significance of PCAT6 in mCRC and its potential use as a prognostic biomarker.

colorectal cancerIncRNAPCAT6metastasis

Xun Sun、Yitao Yuan、Suyao Li、Lu Gan、Midie Xu、Qingguo Li、Mengling Liu、Keshu Hu、Ke Nan、Jiayu Zhang、Yu Dong、Yufu Lin、Xiuping Zhang、Pengcong Hou、Tianshu Liu

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Department of Medical Oncology,Zhongshan Hospital,Fudan University,Shanghai 200032,China

Cancer Center,Zhongshan Hospital,Fudan University,Shanghai 200032,China

Fudan Zhangjiang Institute,Shanghai 201203,China

Department of Pathology and Tissue Bank,Fudan University Shanghai Cancer Center,Shanghai,200032,China

Department of Colorectal Surgery,Fudan University Shanghai Cancer Center,Shanghai,200032,China

Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China

Department of Anesthesiology,Zhongshan Hospital,Fudan University,Shanghai 200032,China

Department of Oncology,Zhongshan Hospital(Xiamen),Fudan University,Xiamen 361015,China

Xiamen Clinical Research Center for Cancer Therapy,Xiamen Branch,Zhongshan Hospital,Fudan University,Xiamen 361015,China

Shanghai Institute of Precision Medicine,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200032,China

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国家自然科学基金国家自然科学基金国家自然科学基金上海市自然科学基金Youth Foundation of Zhongshan Hospital Fudan UniversityXiamen Natural Science Foundation ProjectFujian provincial health technology project

8217292581802370821711149223ZR14213002022ZSQN093502Z202271112021QNB020

2024

生物化学与生物物理学报(英文版)
中国科学院上海生物化学研究所

生物化学与生物物理学报(英文版)

CSTPCD
影响因子:0.772
ISSN:1672-9145
年,卷(期):2024.56(6)
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