The intestinal microbiota coevolves with the host,forming an inseparable host-microbe symbiosis.These symbiotic microbes play an important role in the host immune system by participating in the development and maintenance of adaptive immunity.The adaptive immune system maintains the body's homeostasis through B cell-mediated humoral immunity and T cell-mediated cellular immunity.Intestinal microbiota can directly regulate the differentiation and activation of B and T cells,thus protecting the host from pathogen infections.This article reviews the regulatory effects of intestinal microorganisms on host early immune system development,cellular immunity and humoral immunity,aiming to provide a theoretical reference for studying the regulatory effect of"microbe-host interaction"on host adaptive immunity.
维普
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