Application Progress of Spatially Resolved Metabolomics in Disease Diagnosis Research
Mass spectrometry imaging(MSI)based on spatially resolved metabolomics(SRM)has been recently developed to be a powerful technology.SRM can not only directly identify and quantify the metabolites in animal and plant tissues or cells in situ,but also use overall or local features of the image to determine the structure,content,spatiotemporal dynamic change,and spatial distribution of metabolites.It also may identify potential metabolic biomarkers.This technology has the advantages of high sensitivity,high resolution,judicious visualization and label-free,and therefore has been more and more widely applied in clinical disease diagnosis and research.This review summarizes some of the technological advances of SRM in recent years,and its emerging application in the fields of tumor,neuropsychiatric disorder,diabetes mellitus,among others,in an attempt to guide future application of SRM in disease diagnosis.
万方数据
维普
