Aptamer of Pseudomonas aeruginosa:Acquiring and Application
Pseudomonas aeruginosa is an obligate aerobic Gram-negative bacterium,which is the most important microorganism causing opportunistic infections in humans and poses a variety of health threats to humans.Thus,rapid,sensitive and specific detection is crucial for the prevention and treatment of P.aeruginosa infection.At present,there are problems for conventional detection methods,such as time-consuming,high cost and difficult operation,thus more efficient and economical detection methods are needed.Aptamers are oligonucleotides screened from random libraries that can form a variety of complex secondary structures.In recent years,aptamers have attracted widespread attention due to their ease of synthesis and modification,high affinity and strong specificity,and numerous studies of detection,the prevention and treatment of P.aeruginosa based on aptamers have emerged.In this review,the current progresses in screening and tailoring of P.aeruginosa aptamers were summarized,and the application of its aptamers were introduced from two aspects of detection and control of P.aeruginosa,aiming to provide a reference for the development and application of P.aeruginosa aptamer.
万方数据
维普
