Prediction of H5Nx Avian Influenza Virus Cross-reactivity CD4+T-cell Epitopes
[Objective]To evaluate preexisting H5Nx cross-reactivity immune memory and to provide theoretical data for the prevention and treatment of human H5 avian influenza viruses and the development of broad-spectrum vaccines.[Method]Bioinformatics methods were used to screen the common conserved cross-reactivity CD4+T cell epitopes of human H5Nx avian influenza viruses and seasonal influenza viruses,and further analysis of the nested CD8+T cell epitopes and B cell epitopes of conserved epitopes and their coverage among the Chinese population.[Result]92.3%(513/555)of H5Nx CD4+T cell epitopes were cross-reactivity in seasonal influenza A viruses,of which 172 epitopes nested CD8+T cell epitopes and 5 epitopes nested B cell epitopes.These epitopes and the corresponding HLA-DRB1 alleles have a strong coverage rate of 88.65%in the world population.[Conclusion]Due to repeated exposure to seasonal influenza A viruses,there is a certain level of H5Nx cross-reactivity immune memory in the population that may provide partial protection from H5Nx infection.
国家科技期刊平台
NSTL
万方数据
