Nanozymes with bioorthogonal reaction for intelligence nanorobots

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外文摘要：Bioorthogonal reactions have attained great interest and achievements in various fields since its first appearance in 2003.Compared to traditional chemical reactions,bioorthogonal chemical reactions mediated by transition metals catalysts can occur under physiological conditions in the living system without interfering with or damaging other biochemical events happening simultaneously.The idea of using nanomachines to perform precise and specific tasks in living systems is regarded as the frontier in nanomedicine.Bioorthogonal chemical reactions and nanozymes have provided new potential and strategies for nanomachines used in biomedical fields such as drug release,imaging,and bioengineering.Nanomachines,also called as intelligence nanorobots,based on nanozymes with bioorthogonal reactions show better biocompatibility and water solubility in living systems and perform controlled and adjustable stimuli-triggered response regarding to different physiological environments.In this review,we review the definition and development of bioorthogonal chemical reactions and describe the basic principle of bioorthogonal nanozymes fabrication.We also review several controlled and adjustable stimuli-triggered intelligence nanorobots and their potential in therapeutic and engineered applications.Furthermore,we summarize the challenges in the use of intelligence nanorobots based on nanozymes with bioorthogonal chemical reactions and propose promising vision in smart nanodevices along this appealing avenue of research.

外文关键词：

NanozymesBioorthogonal reactionNanorobotics

作者：

Si Sun、Xinzhu Chen、Jing Chen、Junying Wang、Xiao-dong Zhang

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作者单位：

Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin University, Tianjin 300350, China

Tianjin Key Laboratory of Brain Science and Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China

基金：

This work was financially supported by the National Natural Science Foundation of ChinaThis work was financially supported by the National Natural Science Foundation of ChinaThis work was financially supported by the National Natural Science Foundation of ChinaThis work was financially supported by the National Natural Science Foundation of ChinaThis work was financially supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of TianjinInnovation Foundation of Tianjin University,and CAS Interdisciplinary Innovation Team

项目编号：

9185910181971744U1932107820019528147178619JCZDJC34000JCTD-2020-08

出版年：

2021

生物物理学报

中国生物物理学会中国科学院生物物理研究所

生物物理学报

影响因子：0.355

ISSN：1000-6737

年,卷(期)：2021.7(1)

参考文献量75