首页|Structurally reconfigurable designer RNA structures for nanomachines

Structurally reconfigurable designer RNA structures for nanomachines

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Structurally reconfigurable RNA structures enable dynamic transitions of the functional states in response to diverse molecular stimuli,which are fundamental in genetic and epigenetic regulations.Inspired by nature,rationally designed RNA structures with responsively reconfigurable motifs have been developed to serve as switchable components for building engineered nanomachines,which hold promise in synthetic biological applications.In this review,we summarize recent progress in the design,synthesis,and integration of engineered reconfigurable RNA structures for nanomachines.We highlight recent examples of their targeted applications such as biocomputing and smart theranostics.We also discuss their advantages,challenges as well as possible solutions.We further provide an outlook of their potential in future synthetic biology.

RNA nanomachineStructureReconfigurationBiocomputingTheranostics

Kai Jiao、Yaya Hao、Fei Wang、Lihua Wang、Chunhai Fan、Jiang Li

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Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China

University of Chinese Academy of Sciences,Beijing 100049, China

School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China

This work was supported by the National Key Research and Development ProgramNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaShanghai Municipal Science and Technology CommissionLU JIAXI International team program supported by the K.C.Wong Education Foundation,the National Major Special Project for thOpen Large Infrastructure Research and the Youth Innovation Promotion Association of CASOpen Large Infrastructure Research and the Youth Innovation Promotion Association of CAS

2020YFA09089002177515721775104117052702183400719JC14103002018ZX08011-04B20122052016236

2021

生物物理学报
中国生物物理学会 中国科学院生物物理研究所

生物物理学报

影响因子：0.355
ISSN：1000-6737
年,卷(期)：2021.7(1)
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