首页|AP-3 adaptor complex-mediated vesicle trafficking

AP-3 adaptor complex-mediated vesicle trafficking

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The transport of cargo proteins to specific subcellular destinations is crucial for the different secretory and endocytic traffic pathways.One of the most important steps in maintaining the accuracy of this process is the recruitment of adaptor protein (AP) complexes to the membrane for recognizing and packaging cargo proteins into nascent vesicles.Adaptor protein complex 3 (AP-3) is a heterotetramet-ric complex implicated in the trafficking of cargo proteins from the trans-Golgi network (TGN) and/or endosomes to lysosomes or lysosome-related organelles (LROs).This complex is also involved in the biogenesis of synaptic vesicles (SVs) in neurons and of dense core vesicles (DCVs) in endocrine cells as well as in the recycling of receptors in immune cells and the regulation of planar cell polarity (PCP)proteins.Functional defects in AP-3 cause multiple abnormalities in cellular vesicle trafficking and re-lated organelle function,leading to various disorders,such as Hermansky-Pudlak syndrome (HPS).However,the molecular mechanism underlying AP-3 has not been fully elucidated,and further investi-gations are needed to understand AP-3-mediated trafficking,its associated molecules and its related roles in inherited diseases.Here,we review the current understanding of AP-3 in cellular vesicle traf-ficking,especially focusing on mammalian systems.

AP-3Vesicle traffickingCargo sortingDisease/disorder

Zhuo Ma、Md.Nur Islam、Tao Xu、Eli Song

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National Laboratory of Biomacromolecules,CAS Center for Excellence in Biomacromolecules,Institute of Bio-physics,Chinese Academy of Sciences,Beijing 100101,China

University of Chinese Academy of Sciences,Beijing 100049,China

Guangzhou Regenerative Medicine and Health Guangdong Laboratory (Bioland Laboratory),Guangzhou 510005,China

This work was supported by grants from the Ministry of Science and Technology of the People's Republic of ChinaThis work was supported by grants from the Ministry of Science and Technology of the People's Republic of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaBeijing Natural Science FoundationYouth Innovation Promotion Association of the Chinese Academy of SciencesAll authors participated in the design and discussion of manuscript conception and outline,contributed to editing of the draft m

2018YFA05071012016YFA0500203317709003173005452120162011087

2021

生物物理学报
中国生物物理学会 中国科学院生物物理研究所

生物物理学报

影响因子：0.355
ISSN：1000-6737
年,卷(期)：2021.7(2)
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