首页|Genetic variation and function:revealing potential factors associated with microbial phenotypes

Genetic variation and function:revealing potential factors associated with microbial phenotypes

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Innovations in sequencing technology have generated voluminous microbial and host genomic data,making it possible to detect these genetic variations and analyze the function influenced by them.Re-cently,many studies have linked such genetic variations to phenotypes through association or compar-ative analysis,which have further advanced our understanding of multiple microbial functions.In this review,we summarized the application of association analysis in microbes like Mycobacterium tubercu-losis,focusing on screening of microbial genetic variants potentially associated with phenotypes such as drug resistance,pathogenesis and novel drug targets etc.;reviewed the application of additional comparative genomic or transcriptomic methods to identify genetic factors associated with functions in microbes;expanded the scope of our study to focus on host genetic factors associated with certain mi-crobes or microbiome and summarized the recent host genetic variations associated with microbial phenotypes,including susceptibility and load after infection of HIV,presence/absence of different taxa,and quantitative traits of microbiome,and lastly,discussed the challenges that may be encountered and the apparent or potential viable solutions.Gene-function analysis of microbe and microbiome is still in its infancy,and in order to unleash its full potential,it is necessary to understand its history,current status,and the challenges hindering its development.

Genetic variationPhenotypeAssociation analysisComparative analysisMicrobiome

Xiaolin Liu、Yue Ma、Jun Wang

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CAS Key Laboratory of Pathogenic Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China

University of Chinese Academy of Sciences,Beijing 100049,China

This work was supported by National Key Research and Development Program of ChinaStrategic Priority Research Program of the Chinese Academy of SciencesNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaThanks to all those who has contributed to this work

2018YFC2000500XDB290200003177148191857101

2021

生物物理学报
中国生物物理学会 中国科学院生物物理研究所

生物物理学报

影响因子：0.355
ISSN：1000-6737
年,卷(期)：2021.7(2)
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