首页|The risk model construction of the genes regulated by H3K36me3 and H3K79me2 in breast cancer
The risk model construction of the genes regulated by H3K36me3 and H3K79me2 in breast cancer
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Abnormal histone modifications(HMs)can promote the occurrence of breast cancer.To elucidate the relationship between HMs and gene expression,we analyzed HM binding patterns and calculated their signal changes between breast tumor cells and normal cells.On this basis,the influences of HM signal changes on the expression changes of breast cancer-related genes were estimated by three different methods.The results showed that H3K79me2 and H3K36me3 may contribute more to gene expression changes.Subsequently,2109 genes with differential H3K79me2 or H3K36me3 levels during cancero-genesis were identified by the Shannon entropy and submitted to perform functional enrichment ana-lyses.Enrichment analyses displayed that these genes were involved in pathways in cancer,human papillomavirus infection,and viral carcinogenesis.Univariate Cox,LASSO,and multivariate Cox regres-sion analyses were then adopted,and nine potential breast cancer-related driver genes were extracted from the genes with differential H3K79me2/H3K36me3 levels in the TCGA cohort.To facilitate the ap-plication,the expression levels of nine driver genes were transformed into a risk score model,and its robustness was tested via time-dependent receiver operating characteristic curves in the TCGA dataset and an independent GEO dataset.At last,the distribution levels of H3K79me2 and H3K36me3 in the nine driver genes were reanalyzed in the two cell lines and the regions with significant signal changes were located.
Breast cancerGene expressionH3K79me2H3K36me3Driver genes
Ling-Yu Wang、Lu-Qiang Zhang、Qian-Zhong Li、Hui Bai
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Laboratory of Theoretical Biophysics,School of Physical Science and Technology,Inner Mongolia University,Ho-hhot 010021,China
The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock,Inner Mongolia Uni-versity,Hohhot 010070,China
国家自然科学基金国家自然科学基金国家自然科学基金Scientific Research Program at Universities of Inner Mongolia Autonomous Region内蒙古自治区自然科学基金
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