首页|M6A RNA methylation modification and tumor immune microenvironment in lung adenocarcinoma

M6A RNA methylation modification and tumor immune microenvironment in lung adenocarcinoma

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Lung adenocarcinoma is one of the deadliest tumors.Studies have shown that N6-methyladenosine RNA methylation regulators,as a dynamic chemical modification,affect the occurrence and develop-ment of lung adenocarcinoma.To investigate the relationship between mutations and expression lev-els of m6A regulators in lung adenocarcinoma,we investigated the mutations and expression levels of 38 m6A regulators.We found that mutations in m6A regulatory factors did not affect the changes in ex-pression levels,and 19 differentially expressed genes were identified.All tumor samples were classi-fied into two subtypes based on the expression levels of 19 differentially expressed m6A-regulated genes.Survival analysis showed significant differences in survival between the two subtypes.To ex-plore the relationship between immune cell infiltration and survival in both subtypes,we calculated the infiltration of 23 immune cells in both subtypes,and we found that the subtype with high immune cell infiltration had better survival.We found that subtypes with low tumor purity and high stromal and immune scores had better survival.The m6A-related immune genes were identified by taking the inter-section of differentially expressed genes and immune genes in the two isoforms and calculating the Pearson correlation coefficients between the intersecting immune genes and the differentially ex-pressed m6A-regulated genes.Finally,a prognostic model associated with m6A and associated with im-munity was developed using prognostic genes screened from m6A-associated immune genes.The pre-dictive power of the model was evaluated and our model was able to achieve good prediction.

Lung adenocarcinomaM6A RNA methylation regulatorsConsensus clusteringImmune cell infiltratesTumor immune microenvironment

Shujuan Li、Qianzhong Li、Luqiang Zhang、Yechen Qi、Hui Bai

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Laboratory of Theoretical Biophysics,School of Physical Science and Technology,Inner Mongolia University,Hoh-hot 010021,China

The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock,Inner Mongolia Uni-versity,Hohhot 010070,China

国家自然科学基金国家自然科学基金国家自然科学基金Scientific Research Program at Universities of Inner Mongolia Autonomous Region内蒙古自治区自然科学基金

321602166186103562161033NJZZ210022021BS06001

2023

10.52601/bpr.2023.220020

生物物理学报告(英文)

生物物理学报告(英文)

CSCD
ISSN：
年,卷(期)：2023.9(3)
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