Exploring lysosomal biology:current approaches and methods

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外文摘要：Lysosomes are the degradation centers and signaling hubs in the cell.Lysosomes undergo adaptation to maintain cell homeostasis in response to a wide variety of cues.Dysfunction of lysosomes leads to aging and severe diseases including lysosomal storage diseases(LSDs),neurodegenerative disorders,and cancer.To understand the complexity of lysosome biology,many research approaches and tools have been developed to investigate lysosomal functions and regulatory mechanisms in diverse experi-mental systems.This review summarizes the current approaches and tools adopted for studying lyso-somes,and aims to provide a methodological overview of lysosomal research and related fields.

外文关键词：

LysosomeMethodCultured cellC.elegansMice

作者：

Qiuyuan Yin、Chonglin Yang

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作者单位：

State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan and Center for Life Sciences,School of Life Sciences,Yunnan University,Kunming 650091,China

Southwest United Graduate School,Kunming 650092,China

基金：

国家自然科学基金国家自然科学基金国家重点基础研究发展计划(973计划)Yunnan Province Science and Technology DepartmentProgram of Yunnan Province Leading Talents in Science and Technology

项目编号：

32293200322932012021YFA1300302202001BB050077202105AB160003

出版年：

2024

DOI：

10.52601/bpr.2023.230028

生物物理学报告(英文)

ISSN：

年,卷(期)：2024.10(2)

参考文献量88