首页|Study on the spatial distribution patterns of histone modifications in Hippo pathway genes

Study on the spatial distribution patterns of histone modifications in Hippo pathway genes

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Hippo pathway can regulate cell division,differentiation and apoptosis,and control the shape and size of organs.To study the distribution patterns of histone modifications of Hippo pathway genes in embryonic stem cells is helpful to understand the molecular regulation mechanism of histone modification and Hippo pathway on stem cell self-renewal.In this study,19 genes of Hippo pathway including YAP,TAZ,LATS1/2,MST1 and SAV1,and eight histone modifications in embryonic stem cells were chosen to study the spatial distribution patterns of histone modifications.It was found that there were obvious type specificity and the location preference of target regions in the distributions of histone modifications,and H3K4me3 and H3K36me3 played the most important regulatory roles.Through the correlation analysis of histone modifications,a histone modification functional cluster composed of H3K4ac,H3K4me3,H3K9ac and H3K27ac was detected in YAP.In addition,the spatial distribution patterns of histone modifications in Hippo pathway genes were obtained,which provided a new theoretical reference for elucidating the mechanism of histone modifications regulating the gene expression of Hippo pathway,and for revealing the molecular regulatory mechanism of histone modifications affecting the self-renewal of embryonic stem cells by regulating the Hippo pathway.

Embryonic stem cellHippo pathwayHistone modificationSpatial distribution pattern

Wenxia Su、Dimeng Zhang、Qiang Zhang、Qianzhong Li

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College of Science, Inner Mongolia Agriculture University, Hohhot 010018, China

Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University, Hohhot 010021, China

The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University, Hohhot 010070, China

This work was supported by a grant from the Foundation for basic science research of Inner Mongolia Agricultural UniversityDoctoral Initial Scientific Research Fund of Inner Mongolia Agricultural UniversityScientific and Technological Research Project of Colleges and Universities in Inner MongoliaNational Natural Science Foundation of China

JC2017004NDGCC2016-09NJZY2147331870838

2021

生物物理学报
中国生物物理学会 中国科学院生物物理研究所

生物物理学报

影响因子：0.355
ISSN：1000-6737
年,卷(期)：2021.7(1)
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