首页|Live-cell fluorescence imaging of ciliary dynamics

Live-cell fluorescence imaging of ciliary dynamics

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The cilium was one of the first organelles observed through a microscope.Motile cilia appear as oscil-lating cell appendages and have long been recognized to function in cell motility.In contrast,the far more widespread non-motile cilia,termed primary cilia,were thought to be vestigial and largely ig-nored following their initial description over a century ago.Only in the last two decades has the critical function of primary cilia been elucidated.Primary cilia play essential roles in signal transduction,chemical sensation,mechanosensation and light detection.Various microscopy approaches have been important for characterizing the structure,dynamics and function of the cilia.In this review,we dis-cuss the application of live-cell imaging technologies and their contribution to our current understand-ing of ciliary processes.

CiliaCiliogenesisCiliary dynamicsLive-cell fluorescence imaging

Quanlong Lü、Chuanmao Zhang、Christopher J.Westlake

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Laboratory of Cellular and Developmental Signaling,Center for Cancer Research,National Cancer Institute,Na-tional Institutes of Health,Frederick,MD 21702,USA

Ministry of Education Key Laboratory of Cell Proliferation and Differentiation,College of Life Sciences,Peking University,Beijing 100871,China

We are grateful to Dr.Adrian Cuenca for the critical reading and editing of this manuscript.Q.Lü and C.J.Westlake are supported content of this publication does not necessarily reflect the views or policies of the US Department of Health and Human ServMinistry of Science and Technology of ChinaMinistry of Science and Technology of China

HHSN261200800001E918542042016YFA05002012016YFA0100501

2021

生物物理学报
中国生物物理学会 中国科学院生物物理研究所

生物物理学报

影响因子：0.355
ISSN：1000-6737
年,卷(期)：2021.7(2)
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