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Latest developments on the mechanism of action of membrane disrupting peptides
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Antimicrobial peptides(AMPs)are integral components of the innate immune defence system of all complex organisms including plants,insects,and mammals.They have wide range of antibacterial,anti-fungal,antiviral,and even anticancer activities,therefore AMPs are attractive candidates for develop-ing novel therapeutic approaches.Cationic α-helical membrane disrupting peptides are perhaps the most widely studied subclass of AMPs due to their common fundamental characteristics that allow for detailed structure-function analysis and therefore offer a promising solution to the threat of multidrug resistant strains of bacteria.The majority of the studies of AMP activity focused on the biological and biophysical aspects of membrane disruption;the understanding of the molecular mechanism of action from the physicochemical point of view forms a relatively small subfield.This review will provide an overview of these works,focusing on the empirical and thermodynamic models of AMP action.
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