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Mutual interaction of microbiota and host immunity during health and diseases

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Microbiota-host interaction has attracted more and more attentions in recent years.The association between microbiota and host health is largely attributed to its influence on host immune system.Microbial-derived antigens and metabolites play a critical role in shaping the host immune system,including regulating its development,activation,and function.However,during various diseases the microbiota-host communication is frequently found to be disordered.In particular,gut microbiota dysbiosis associated with or led to the occurrence and progression of infectious diseases,autoimmune diseases,metabolic diseases,and neurological diseases.Pathogenic microbes and their metabolites dis-turb the protective function of immune system,and lead to disordered immune responses that usually correlate with disease exacerbation.In the other hand,the immune system also regulates microbiota composition to keep host homeostasis.Here,we will discuss the current advances of our knowledge about the interactions between microbiota and host immune system during health and diseases.

MicrobiotaMicrobial-derived antigens and metabolitesImmune systemComposition of microbiotaHost health and diseases

Di Wu、Yinlian Zhang、Suwei Dong、Chao Zhong

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Institute of Systems Biomedicine,Department of Immunology,Beijing Key Laboratory of Tumor Systems Biology,Peking University Health Science Center,Beijing 100191,China

State Key Laboratory of Natural and Biomimetic Drugs,Department of Chemical Biology,School of Pharmaceuti-cal Sciences,Peking University,Beijing 100191,China

317709579184210218G10645

2021

生物物理学报
中国生物物理学会 中国科学院生物物理研究所

生物物理学报

影响因子：0.355
ISSN：1000-6737
年,卷(期)：2021.7(4)
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