Review on IRES-mediated cap-independent translation regulation
Internal ribosome entry site(IRES)is a special functional element in RNA,which can directly recruit ribosome to initiate protein translation independently of the 5'end cap structure.It has been found to be closely related to a variety of cell processes.Recently,IRES have attracted a lot of attention due to increasing evidence that they play an extremely important role in the regulation of circular RNA translation.This paper reviews the current mechanism of IRES-mediated translation regulation in eukaryotic cells,and summarizes the bioinformatics tools related to IRES elements.
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