Entropy changes during the proliferation of heterogeneous stem cells
Adult stem cells are found throughout the body and play an important role in tissue growth,development,aging,and wound healing.Stem cell regenerations are tightly regulated in normal tissues.Abnormal stem cell regeneration is closely associated with many diseases such as malignant tumors,obesity,aplastic anemia,etc.Heterogenous stem cell regeneration within living organisms is a complex dynamical system behavior.The abnormal cell proliferation includes processes of establishing a new balance along with cell plasticity and cell-to-cell interactions.It is a significant research topic to quantitatively describe the biological process of abnormal cell growth.This paper establishes a computational model of stem cell regeneration that incorporates proliferation and differentiation indicators of cells,as well as indicators of abnormal proliferation heterogeneity.Through the established model,the process of microenvironment changes-induced abnormal cell growth and the entropy evolution dynamics are studied.Moreover.the relationship between entropy dynamics and kinetic parameters under different proliferation conditions.Results show that during abnormal cell growth induced by microenvironmental changes,there exists a correspondence between entropy and the number of cells,which is independent of the pathway of microenvironmental changes.In addition,the dependence of entropy on cell number shows different behaviors during the abnormal proliferation and the recovery process,which suggests the irreversibility of the microscopic biological process.This paper presents a quantitative characterization of the entropy changes during abnormal cell growth through a physics perspective.It provides a new research approach for quantitative studies of the heterogeneous stem cell regeneration process.
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