Bioinformatics analysis of differentially expressed genes in zebrafish liver after acute exposure to inorganic arsenic
Arsenic is a carcinogen and a causative agent of cardiovascular and peripheral vascular disease,neurological disorders,diabetes mellitus and various forms of cancer.Objective:Used Bioinformatics methods such as GO database and KEGG database to evaluate the differentially expressed genes in GEO database data.Methods:Functional enrichment,functional annotation analysis and survival analysis of the differential genes were performed by using bioinformatics analysis software.Results:Used protein-protein interaction network(PPI)software on Cytoscape to analyze 179 differential genes.A total of 126 genes were found to be acting on protein targets,and 10 of them were key genes,respectively:PSMB3,HSP701,HSPE1,STIP1,HSPD1,HSP70,DNAJB1B,HSP90AA1.1,HSP A9H,TCP1;Conclusion:The core genes mainly act on protein processing in endoplasmic reticulum pathway.It provides a new research direction for the potential biomarkers and biological mechanisms of arsenic induced liver injury.
国家科技期刊平台
NSTL
万方数据
