宏观压痕测量血管壁力学性能方法的研究
Study on methods measuring mechanical properties of arterial wall by macroscopic indentation
曹祎凡 1高志鹏 1石怡柯 1李芬 2宋辉 2张倩倩 1赵雅威 1陈凌峰 1李晓娜 1陈维毅1
作者信息
- 1. 太原理工大学 生物医学工程学院(太原 030024)
- 2. 太原理工大学 机械与运载工程学院(太原 030024);太原理工大学 应用力学研究所(太原 030024)
- 折叠
摘要
在动脉疾病的诊断和治疗中,有效评估血管壁局部生物力学特性至关重要.压痕测量可用于评估动脉局部力学性能,但压头的几何结构和分析理论对测量结果的影响尚不清楚.本文采用4种压头对猪的肺动脉、胸主动脉近心端和胸主动脉远心端进行测量,并通过斯内登(Sneddon)和瑟尔吉(Sirghi)理论计算动脉弹性模量,探究压头几何结构和分析理论对弹性模量测量值的影响.结果显示,圆柱形压头测量的动脉弹性模量值低于球形压头测量值;其次,与Sirghi理论计算结果相比,通过不考虑黏附力的Sneddon理论获得的动脉弹性模量值略大.综上,本研究可为毫米级压痕技术有效测量动脉局部力学特性提供参数支持.
Abstract
Accurately evaluating the local biomechanics of arterial wall is crucial for diagnosing and treating arterial diseases.Indentation measurement can be used to evaluate the local mechanical properties of the artery.However,the effects of the indenter's geometric structure and the analysis theory on measurement results remain uncertain.In this paper,four kinds of indenters were used to measure the pulmonary aorta,the proximal thoracic aorta and the distal thoracic aorta in pigs,and the arterial elastic modulus was calculated by Sneddon and Sirghi theory to explore the influence of the indenter geometry and analysis theory on the measured elastic modulus.The results showed that the arterial elastic modulus measured by cylindrical indenter was lower than that measured by spherical indenter.In addition,compared with the calculated results of Sirghi theory,the Sneddon theory,which does not take adhesion forces in account,resulted in slightly larger elastic modulus values.In conclusion,this study provides parametric support for effective measurement of arterial local mechanical properties by millimeter indentation technique.
关键词
生物力学/动脉/压痕实验Key words
Biomechanics/Arteries/Indentation tests引用本文复制引用
基金项目
国家自然科学基金(12002231)
国家自然科学基金(12072218)
山西省国家卫生健康委员会重点科研计划(20410710100)
出版年
2024
NETL
NSTL
万方数据