摘要
聚氨酯材料具有良好的生物相容性、血液相容性、力学性能、耐疲劳性和可加工性,一直以来都是备受关注的生物医用材料.利用静电纺丝技术制备的聚氨酯纤维能够较好地模拟天然细胞外基质(ECMs)结构,种子细胞可较好地黏附和增殖,满足组织修复和重建的要求.本综述旨在通过介绍静电纺聚氨酯纤维在骨组织工程、皮肤组织工程、神经组织工程、血管组织工程和心脏组织工程方面的研究进展,帮助研究人员深入了解静电纺聚氨酯纤维在组织工程和再生医学中的实际应用.
Abstract
Polyurethane materials have good biocompatibility,blood compatibility,mechanical properties,fatigue resistance and processability,and have always been highly valued as medical materials.Polyurethane fibers prepared by electrostatic spinning technology can better mimic the structure of natural extracellular matrices(ECMs),and seed cells can adhere and proliferate better to meet the requirements of tissue repair and reconstruction.The purpose of this review is to present the research progress of electrostatically spun polyurethane fibers in bone tissue engineering,skin tissue engineering,neural tissue engineering,vascular tissue engineering and cardiac tissue engineering,so that researchers can understand the practical applications of electrostatically spun polyurethane fibers in tissue engineering and regenerative medicine.
基金项目
山东省重点研发计划(重大科技创新工程)(2019JZZY011108)
NETL
NSTL
万方数据