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基于力学杀菌机制的纳米结构表面研究进展

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细菌耐药性问题一直悬而未决,近些年来,受自然界启发的仿生纳米结构表面因通过力学机制展示杀菌特性而受到了极大的关注.本文综述了纳米结构力学杀菌表面领域的主要研究进展,包括具有力学杀菌性能的纳米结构表面的各种制备方法,以及细菌与纳米结构表面相互作用的基本机制和相关的物理模型;此外,还介绍了纳米结构表面在生物医学中的应用.最后,对力学杀菌研究面临的重大挑战和未来研究发展方向进行了展望.
Advances in nanostructured surfaces for enhanced mechano-bactericidal applications
The issue of bacterial drug resistance has remained unresolved,and in recent years,biomimetic nanostructured surfaces inspired by nature have garnered significant attention due to their bactericidal properties demonstrated through mechanical mechanisms.This article reviewed the main research progress in the field of nanostructured mechanical bactericidal surfaces,including various preparation methods for nanostructured surfaces with mechanical bactericidal properties,as well as the basic mechanisms and related physical models of the interaction between bacteria and nanostructured surfaces.In addition,the application of nanostructured surfaces in biomedicine was introduced.Finally,the article proposed the major challenges faced by mechanical bactericidal research and the future development direction.

NanostructureMechanical bactericidalBactericidal mechanismDrug resistance

陈世雄、梁英、田晓宝、王凯

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四川大学建筑与环境学院深地科学与工程教育部重点实验室(成都 610065)

北京航空航天大学生物与医学工程学院(北京 100191)

纳米结构 力学杀菌 杀菌机制 耐药性

国家自然科学基金国家科技重大专项

12372154J2019-Ⅲ-0010-0054

2024

生物医学工程学杂志
四川大学华西医院 四川省生物医学工程学会

生物医学工程学杂志

CSTPCD北大核心
影响因子:0.432
ISSN:1001-5515
年,卷(期):2024.41(5)