Correlation analysis of different ultrasound features and histological grading of breast cancer
Objective To investigate the correlation between ultrasound features and histological grading of breast malignant nodules.Methods A total of 141 patients with breast cancer diagnosed by pathology were enrolled,which aged 31-79 years old with mean age of 54.2 years old;disease duration was 1-5 years with mean duration of 3.7 years;tumor diameter was 7-30 mm with mean diameter of 20.3 mm.All of them performed two-dimensional ultrasound and color Doppler flow imaging(CDFI),the observation indexes included nodule morphology,boundary,aspect ratio,microcalcification,posterior a coustic attenuation,internal blood flow and axillary lymph nodes.According to degree of glandular tube formation,nuclear pleomorphism and mitotic count,the pathological histologic grading was classified as grade Ⅰ,Ⅱ,and Ⅲ.The correlation between ultrasound features of breast cancer nodules and their histologic grading and grading indexes was statistically ana-lyzed.Results All of 141 breast cancer nodules were invasive breast cancer,with 24 cases of grade Ⅰ,72 of grade Ⅱ,and 45 of grade Ⅲ in pathological histologic grading.The difference of microcalcifications among different pathophysiologic grades was sta tistically significant[51.77％(73/141)vs 48.23％(68/141).P＜0.05].Nevertheless there no statistically significant difference of other ultrasound observation indexes(morphology,boundaries,aspect ratio,peripheral strong echogenicity acoustic halo,posterior attenu ated acoustic shadows,internal blood flow,and axillary lymph node metastasis)among different pathophysiologic grades groups(P＞0.05).In addition,the difference of microcalcification between the degree of glandular tube formation and mitotic count of nodules was statistically significant[(2.77±0.46)scores vs(2.59±0.57)scores and(1.66±0.77)scores vs(1.41±0.68)scores.P＜0.05],and there was no significant difference in nuclear pleomorphism(P＞0.05)among different pathophysiologic grades groups.Conclusion It is demonstrated that microcalcification in ultrasound images of malignant breast nodes correlate with histological grading and their indicators and are important imaging indicators for interpreting the prognosis of malignant breast nodes.
breast cancerultrasound diagnosispathology diagnosishistological grading
NETL
NSTL
万方数据
维普
