Effect of hemodialysis filtration on nutritional status of maintenance hemodialysis patients
Objective To observe the effect of hemodiafiltration(HDF)on nutritional status in maintenance hemodialysis(MHD)patients.Methods A total of 46 hemodialysis patients performed MHD treatment were enrolled,which included 28 males and 18 females,aged 19-80 years old with mean age of 60.8 years old.There were 21 cases of chronic nephritis,15 of diabetic nephropathy and 10 of other causes.According to treatment methods,all of them were divided into HDF group(n=28)and high-flux haemodialysis(HF-HD)group(n=18).The HF-HD group was performed with 3 HF-HD per week,and HDF group was treated with 2 HF-HD and 1 HDF per week.The serum albumin,renal function,electrolyte,blood routine,C-reactive protein(CRP)and parathyroid hormone before treatment and 12-month post treatment between 2 groups were compared.The bioelectrical impedance method was used to evaluate the changes of body mass index,skeletal muscle,upper arm circumfer-ence,upper arm muscle circumference,visceral fat area and other nutritional indicators before treatment and 12-month post treatment.Results After treatment for 12-month,the albumin level in HDF group was significantly higher than that in HF-HD group[(39.06±3.02)g/L vs(36.84±3.21)g/L],and CRP was remarkably lower than that in HF-HD group[(4.44±5.34)mg/L vs(8.78±8.60)mg/L].In addition,the albumin level in HDF group was significantly higher 12-month post treatment than that before treatment,while CRP index in HF-HD group was significantly higher than that before treatment,and the difference was statistically signifiicant[(37.14±3.69)g/L vs(39.06±3.02)g/L,(5.76±6.61)mg/L vs(8.78±8.60)mg/L.P＜0.05].More-over,the upper arm muscle circumference in HDF group was significantly higher than that in HF-HD group[(24.07±1.94)cm vs(22.38±1.60)cm],the circumference of skeletal muscle and upper arm muscle in HF-HD group was significantly low-er than that before treatment[(25.07±4.77)kg vs(21.74±3.29)kg,(23.81±1.53)cm vs(22.38±1.60) cm.P＜0.05],12-month post treatment.Conclusion It is demonstrated that compared with simple HF-HD treatment,MHD patients receiving 1 HDF per week could maintain muscle mass and visceral fat mass,reduce uremia and dialysis-related inflammation,and improve nutritional status.It is worthy of promotion and application.
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NSTL
万方数据
维普
