Objective To explore the changes of myocardial tissue and cardiac function in patients with acquired immunodefi-ciency syndrome(AIDS)by cardiac magnetic resonance(CMR)enhanced scanning.Methods A total of 56 patients with AIDS were enrolled(observation group),which included 42 males and 14 females,aged 21.2-57.6 years old with mean age of 40.50 years old;body mass index(BMI)was 18.3-26.1 kg/m2 with mean BMI of 22.21 kg/m2.Meantime,56 patients with human immunodeficiency virus(HIV)infection were set as control group,which included 40 males and 16 females,aged 20.5-59.4 years old with mean age of 39.69 years old;BMI was 18.0-25.8 kg/m2 with mean BMI of 22.15 kg/m2.All of them performed CMR enhanced scanning,and the differences in CMR examination parameters between 2 groups were compared.Results The incidence of cardiac injury of observation group was 37.50％,which was higher than that of control group(P＜0.05).The left ventricular myocardial mass(LVM),area under myocardial perfusion curve,and relative peak signal intensity of observation group were(80.15±11.43)g,(48.82±5.12)％,and(40.05±5.09)％,which were significantly lower than those of control group(P＜0.05).The left ventricular remodeling index(LVRI),time to peak and proportion of late gadolinium en-hancement(LGE)in left ventricular mass were 1.51±0.12,(40.84±6.18)seconds and(3.72±0.96)％,respectively,which were significantly higher than those of control group(P＜0.05).In addition,there was no significant difference in left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV),left ventricular stroke volume(LVSV),left ventricu-lar ejection fraction(LVEF),right ventricular end-diastolic volume(RVEDV),right ventricular end-systolic volume(RVESV),right ventricular stroke volume(RVSV)and right ventricular ejection fraction(RVEF)between 2 groups(P＞0.05).There was no significant difference in LVEDV,LVESV,LVSV,LVEF,LVM,LVRI,RVEDV,RVESV,RVSV and RVEF for pa-tients with different disease course of observation group(P＞0.05).In observation group,the area under myocardial perfusion curve and relative peak signal intensity in patients with disease course≥12 months were(47.31±5.02)％and(37.91±5.12)％,respectively,which were significantly lower than those in patients with disease course＜12 months(P＜0.05).Nevertheless in patients with disease course≥12 months,the time to peak and proportion of LGE in left ventricular mass were(42.85±5.93)seconds and(3.92±0.93)％,respectively,which were significantly higher than those in patients with disease course＜12 months(P＜0.05).There were no significant differences in LVEDV,LVESV,LVSV,LVEF,LVM,LVRI,RVEDV,RVESV,RVSV,RVEF,area under myocardial perfusion curve,relative peak signal intensity,time to peak and LGE to left ventricular mass ratio among patients with different viral loads of observation group(P＞0.05).Conclusion It is demonstrated that myocar-dial tissue and cardiac function of patients with AIDS are changed,and CMR can assess the myocardial injury of patients in early stage.
cardiac magnetic resonanceenhanced scanningacquired immunodeficiency syndromemyocardial tissuecardiac function
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