Evaluation of performance of Mindray BC-6800 Plus automatic blood analyzer CDR channel mode detection of platelet pseudo-abnormal by resistance method
Objective To evaluate the performance of 8-fold multiplication mode of Mindray BC-6800 Plus automatic blood analyzer(BC-6800 Plus analyzer)--using optical method principle+semiconductor laser+RNA nucleic acid fluorescence staining method(CDR)in detecting of pseudo-abnormality in platelet(PLT)by resistance method.Methods From February 2021 to May 2023,a total of 89 cases of PLT pseudo-abnormal specimens were detected by BC-6800 Plus analyzer.The re-sistance method,CDR channel mode and manual counting method were used to detect PLT,and the differences of results from the three methods were compared.At the same time,CDR channel mode was used to continuously detect PLT for 10 times and evaluate its repeatability,and manual counting method was used as reference to evaluate its accuracy and consistency.Results The outcome of pseudo-elevated specimens of CDR channel mode of BC-6800 Plus analyzer in detection of PLT by resistance method[(231.81±57.75)× 109/L]were significantly lower than those by resistance method[(586.81±124.99)× 109/L],while the outcome of pseudo-abnormal reduction specimens of[(189.37±51.06)× 109/L]were significantly higher than those of resistance method[(43.52±20.10)× 109/L],and the differences were statistically significant(P＜0.05).However,the outcomes had no signif-icant differences when compared with that of manual counting method(P＞0.05).The specimen CV values pseudo-elevated specimens and pseudo-abnormal reduction specimens of detection PLT increase and decrease by resistance method CDR channel mode of BC-6800 Plus analyzer by 4.33％and 5.20％,respectively,both＜10.00％.The results of manual counting were used as the target value,the Bias of pseudo-elevated specimens and pseudo-abnormal reduction specimens of PLT detected by BC-6800 Plus analyzer CDR channel mode increase and decrease by 7.56％and-5.28％,respectively,both＜10.00％.By Pearman cor-relation analysis,the pseudo-abnormal specimens of BC-6800 Plus analyzer CDR channel mode detection resistance method PLT and manual counting method results showed a significant positive correlation(relevated specimen=0.961 3,rreduced specimens=0.940 1,P＜0.05).Conclusion It is demonstrated that BC-6800 Plus analyzer CDR channel pattern detection shows good consistency in pseudo ab-normal PLT specimens detected by resistance method and that by manual counting methods.It has good repeatability and high ac-curacy,and can resist detection interference from red blood cell(RBC)debris,small RBC,large PLT and PLT aggregation,which is worthy of clinical application.
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