Effects of Probiotics Supplementation on Blood Glucose Control and Lipid Metabolism in Patients with Type 2 Diabetes
Objective To evaluate the effect of probiotics supplementation on blood glucose and lipids in patients with type 2 di-abetes mellitus(T2DM).Methods The subjects were 60 patients with T2DM.The patients take bifidobacterium lactobacillus triple viable tablets every day and take them orally before three meals for 90 days.Blood samples were collected on the first day(T1)and the last day(T90)of the intervention,and the levels of fasting blood glucose,triglyceride,high-density lipoprotein cholesterol(HDL-c),low-density lipoprotein cholesterol(LDL-c),extremely low-density lipoprotein cholesterol(VLDL-c)and total cholesterol were measured by automatic biochemical analyzer.After taking probiotics,the concentration of E.coli in the intestine was evaluated ev-ery 15 days until the end of the 90-day test.Results After taking probiotics for 90 days,the blood glucose level of patients decreased significantly(P<0.05);The HDL-c value of patients increased significantly(P<0.05).After 15 days of supplementation with probiot-ics,the changes of E.coli in the intestines of patients can be observed.With the increase of supplementation time,the number of Escherichia coli in patients'intestines gradually decreased.Conclusion Probiotics supplementation significantly reduced fasting blood glucose in T2DM patients,and promoted the improvement of blood lipids and intestinal health.These results suggest that pro-biotics supplementation may be an appropriate adjunctive therapy for blood glucose control in T2DM patients.
万方数据
维普
