The Correlation between Neutrophil/Lymphocyte Ratio and Cognitive Impairment in Patients with Acute Cerebral Infarction
Objective To examine the impact of systemic inflammation represented as the neutrophil-lymphocyte ratio(NLR)on the development of post-stroke cognitive impairment(PSCI)at 3-month after acute cerebral infarction.Method The research sub-jects were 170 patients with acute cerebral infarction.According to the results of the 3-month Mini Mental State Examination(MMSE)after cerebral infarction,patients were divided into a non cognitive impairment group(n=137)and a post infarction cogni-tive impairment(PSCI)group(n=35).In addition,patients were divided into Q1(≤1.57),Q2(1.58～2.01),Q3(2.02～2.55),Q4(2.56～3.79),and Q5(≥3.80)groups based on the admission NLR quintile,with 34 patients in each group.Evaluate the correlation between NLR and PSCI using logistic regression analysis.Result The NLR of the PSCI group was higher than that of the non-cogni-tive impairment group(P<0.05).The incidence of PSCI in Q5 group was also higher than that in other groups(all P<0.05).In logis-tic regression analysis,NLR is an important predictor of PSCI;In addition,compared to the Q1 group,the Q5 group was significant-ly associated with a 3.264 fold increase in PSCI risk.Conclusion NLR in the acute stage of ischemic stroke was independently asso-ciated with PSCI at 3 months after cerebral infarction.
cerebral infarctionmini mental state examinationinflammationcognitive impairment
万方数据
维普
