Optimizationon of the Synthesis Process of Diazepam
In the synthesis of diazepam,ammonium bicarbonate,ammonium carbonate and HA were compared respectively,and the effect and yield of ammonium bicarbonate cyclic in diazepam synthesis were better.In further experiments,the optimal syn-thesis conditions were found by adjusting the mass ratio,reaction temperature and reaction time of 2-(N-methyl-chloroacetamide)-5-chlorobenzbenone and ammonium bicarbonate.The results showed that the reaction temperature of 52℃and the reaction time of 7 h had a significant effect on the synthesis yield of diazepam,with the highest mass yield of diazepam when 2-(N-methyl-chloro-acetyl)-5-chlorophenone and ammonium bicarbonate was 1∶6.In the resulting reliability validation experiment,three replicate ex-periments were performed with synthetic yields of 84.8%,84.7%and 84.9%,which further showed that the yield of synthetic diaze-pam was relatively stable and reliable under this process condition.
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