首页|丁苯酞与阿司匹林联合治疗急性脑梗死的临床效果观察

丁苯酞与阿司匹林联合治疗急性脑梗死的临床效果观察

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目的 进一步探讨丁苯酞在治疗急性脑梗死方面的临床作用.方法两组急性脑梗死患者在临床治疗上都执行基础治疗方案,对照组服用阿司匹林,研究组在对照组的治疗基础上加用丁苯酞注射液.对两组患者进行14d的临床持续观察,包括疗效、神经功能与日常生活能力、氧化应激等.结果 对照组患者总有效率为71.9%,研究组患者总有效率为93.7%,两组对比存在显著差异(P<0.05).两组患者治疗后的NIHSS评分和Barthel指数得分,研究组明显好于对照组(P<0.05).两组患者血清AOPP、MDA都出现明显下降,且对照组明显高于研究组.两组患者血清SOD、GSH-PX也都明显提升,且对照组明显低于研究组.两组患者在氧化应激观察指标上的对比存在显著差异(P<0.05).结论 丁苯酞联合阿司匹林治疗急性脑梗死效果显著,值得推广.
Clinical Effect of the Combination Therapy of Butylphthalein and Aspirin in the Treatment of Acute Cerebral Infarction
Objective To further discuss the clinical effect of butyphthalide in the treatment of acute cerebral infarction.Meth-ods Both groups performed basic treatment in clinical treatment,the control group took aspirin on the basis of conventional treat-ment,and the study group added bulphthalin injection on the basis of control treatment.Both groups were observed continuously for 14d,including efficacy,neurological function and daily living ability,and oxidative stress.Result The total effective rate of the con-trol group was 71.9%,and the total effective rate of the study group was 93.7%.The comparison between the two groups was statisti-cally different,(P<0.05);the NIHSS score and Barthel index scores of the two groups were significantly better than the control group with significant differences and statistically significant,(P<0.05);serum AOPP and MDA in both groups decreased significant-ly,but the control group was significantly higher than that of the study group.In addition,the serum SOD and GSH-PX in both groups were also significantly improved,but the control group was significantly lower than that of the study group.There was a sig-nificant difference in the observation indicators of oxidative stress between the two groups of patients(P<0.05).Conclusion The combination of bulphthalide and aspirin in the treatment of acute cerebral infarction is very effective and worth promoting.

buphenphthalinaspirinacute cerebral infarction

纪宁

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山西大同大学附属医院神经内科,山西大同 037008

山西大同大学医学院,山西大同 037008

丁苯酞 阿司匹林 急性脑梗死

2024

山西大同大学学报(自然科学版)
山西大同大学

山西大同大学学报(自然科学版)

影响因子:0.271
ISSN:1674-0874
年,卷(期):2024.40(4)