Effects of Non-steroidal Anti-inflammatory Drugs on Chronic Atrophic Gastritis and Its Coping Strategies
Objective This study was conducted to investigate the effects of non-steroidal anti-inflammatory drugs(NSAIDs)on gastric mucosal injury in patients with chronic atrophic gastritis(CAG),and to evaluate the effectiveness of coping strategies against the effects.Methods From 2019 to February 2024,120 patients diagnosed with chronic atrophic gastritis by gastroscopy and pathology were enrolled in this study and randomly divided into control group(n=60)and experimental group(n=60).The control group only received conventional treatment(including gastric mucosal protection agents,gastric motogenic drugs,etc.),while the experimental group continued to take NSAIDs(such as aspirin,with an average dose of 75 mg/day)on the basis of con-ventional treatment.The main outcome measures included the degree of gastric mucosa atrophy(quantified by gastroscopic biopsy pathology score,ranging from 0 to 4 points,the higher the score was,the more severe the atrophy was.At baseline,the score of the two groups was 2.67±0.34 vs 2.71±0.31),the eradication rate of Helicobacter pylori(HP),and symptom score(using visual analog score,ranging from 0 to 10 points).Higher scores were associated with more severe symptoms(6.52±1.28 vs 6.48±1.32 at baseline)and quality of life assessment SF-36 scale,out of 100,higher scores were associated with better quality of life(62.45±7.89 vs 63.12±8.04 at baseline).The follow-up period was 12 months,and the changes of the above indexes were recorded reg-ularly.Results After 12 months of treatment,the score of gastric mucosa atrophy in the control group was significantly decreased to 1.34±0.26(P<0.05),while the score in the experimental group was only slightly decreased to 2.21±0.39(P＞0.05),and the difference between groups was significant(P<0.05).The eradication rate of Helicobacter pylori was 83.33%(50/60)in control group and 66.67%(40/60)in experimental group,the difference was statistically significant(x2=4.23,P<0.05).Symptom scores in the control group decreased from 6.52±1.28 to 2.15±0.87 at baseline(P<0.05)and in the experimental group from 6.48±1.32 to 4.27±1.14(P<0.05),with significant differences between the groups(P<0.05).The SF-36 score of the control group was in-creased from 62.45±7.89 to 85.67±6.43(P<0.05),and that of the experimental group was increased from 63.12±8.04 to 74.32±7.56(P＞0.05),and the difference between the groups was also significant(P<0.05).Conclusion In this study,long-term use of NSAIDS significantly increased the degree of gastric mucosa atrophy in patients with chronic atrophic gastritis,decreased the erad-ication rate of Helicobacter pylori,and affected the relief of symptoms and the improvement of quality of life.
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