Correlation Analysis Between Hyponatremia and Adverse Outcomes after Acute Cerebral Infarction Reperfusion
Objective To evaluate the impact of admission hyponatremia(serum sodium<136 mmol/L)on adverse outcomes in patients with acute cerebral infarction treated with intravenous thrombolysis or endovascular thrombectomy therapy.Methods A to-tal of 170 patients with acute cerebral infarction who were treated with intravenous thrombolysis with alteplase within 4.5 hours or endovascular thrombectomy within 6 hours after onset were enrolled in this study.According to the serum sodium test on admission,the patients were divided into hyponatremia group(n=23)and non-hyponatremia group(n=147).The in-hospital outcomes,includ-ing symptomatic intracranial hemorrhage and mortality,and poor functional outcome(mRS>2)at 3 months after discharge were ob-served.Results Compared with patients without hyponatremia,patients with hyponatremia were older and had higher Charlson co-morbidity index(CCI)(all P<0.05).Compared with patients without hyponatremia,patients with hyponatremia were more likely to have poor functional outcome(mRS>2)at 3 months after discharge(P<0.05).Multivariate logistic regression analysis showed that hyponatremia was associated with poor functional outcome(OR 1.763,95%CI 1.120～2.764,P=0.014)and in-hospital mortality(OR 2.391,95%CI 1.231～4.678,P<0.001).Conclusion Hyponatremia at admission is independently associated with poor outcome after reperfusion in patients with acute cerebral infarction treated with intravenous thrombolysis or endovascular thrombectomy.Fu-ture studies should address whether correcting hyponatremia improves outcomes.
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