Research Progress of ROCK2 Regulated Microglia Polarization in Prevention and Treatment of Alzheimer's Disease
Microglia(MG)regulated neuroinflammatory response plays critical roles on the pathogenesis of Alzheimer's dis-ease(AD).When brain homeostasis is disrupted,MG is activated.MG has two phenotypes:M1 phenotype and M2 phenotype.M1-like MG secretes pro-inflammatory factors,leading to neurotoxicity;M2-like MG secretes anti-inflammatory factors and plays the role of anti-inflammatory and damage repair.Promoting the conversion of MG from M1 phenotype to M2 phenotype is considered as an effective way for AD therapy.ROCK2,a serine/threonine kinase,is abnormally activated in the brains of AD patients and AD animal models.Previous studies have proved that inhibition of ROCK2 activity can promote the conversion of MG from M1 to M2 phenotype in the brains of AD mice,and significantly attenuates the neuroinflammation of AD mice.The present article focuses on recent findings regarding the down regulation of ROCK2 activity in regulation MG polarization to prevent AD.
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