Analysis of Astragalus Walnut Drink Against Dementia from Superoxide Dismutase
Objective To analyze the efficacy and mechanism of action of Astragalus walnut drink on Alzheimer's disease mod-el mice(APP/PS1 Tg).Methods 8-month-old APP/PS1 double transgenic male mice(Alzheimer's disease model mice,APP/PS1 Tg)were randomly divided into the Alzheimer's disease model group and the Astragalus walnut drink group(traditional Chinese medicine group),and 8-month-old C57BL/6 male mice were used in the wild control group.Differences in superoxide dismutase content and distribution of TUNEL in the hippocampus were compared among the three groups of mice.Results①There was a dif-ference in SOD between the Chinese medicine group and the wild group after treatment,and there was a significant difference with the Alzheimer's disease model group;②About the distribution of TUNEL in the hippocampus,there was no difference between the Chinese medicine group and the wild group after treatment,and there was a significant difference with the Alzheimer's disease mod-el group.Conclusion The improvement of cognitive function in APP/PS1 mice treated with Astragalus Walnut Drink is related to its antioxidant capacity.
astragalus walnut drinkAlzheimer's diseasesuperoxide dismutaseTUNELspleen and kidney deficiency
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